Stimulating the gene expression of several selenoproteins in broilers
In animals 26 SeCys containing selenoproteins have been identified, all having essential functions, several of which directly detoxify oxidants. In chicken tissues selenium availability and stress are the main drivers for selenoprotein expression.
Selisseo, a pure form of organic selenium, provides adequate selenium levels for SeCys de novo synthesis and selenoprotein gene expression and activity.
Screening of the complete selenogenome (Cornell University, USA), in different tissues of broiler chickens, revealed that Selisseo® stimulates the expression of selenoproteins both at gene and protein levels. In particular, the expression of genes related to antioxidant function and maintenance of optimal cell selenium status was increased with Selisseo®. Further gene expression results also revealed improvements in the expression of several selenoproteins in both breast and thigh muscles. Notably several known to have antioxidant (glutathione peroxidases (GPx), methionine sulfoxide reductase B1) and anti-inflammatory functions (selenoprotein S and K). Increases were also seen in SepSecS, which is an enzyme involved in the expression of all selenoproteins. Selenoprotein P, the major selenoprotein involved in selenium homeostasis, was highly influenced by the selenium source fed.
Using Selisseo® in broilers feed helps stimulating the expression of selenoproteins gene in broilers, which guarantees a strong protection from the effects of stress.
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